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Androgen insensitivity syndrome AIS is an intersex condition that results in the partial or complete inability of the cell to respond to androgens. AIS is divided into three categories that are differentiated by the degree of genital masculinization : complete androgen insensitivity syndrome CAIS is indicated when the external genitalia are those of a typical female; mild androgen insensitivity syndrome MAIS is indicated when the external genitalia are those of a typical male, and partial androgen insensitivity syndrome PAIS is indicated when the external genitalia are partially, but not fully, masculinized. Management of AIS is currently limited to symptomatic management ; no method is currently available to correct the malfunctioning androgen receptor proteins produced by AR gene mutations.

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